Buy Paroxetine Online
Paroxetine is used for treating depression or obsessive-compulsive disorder (OCD). It may be used to treat panic disorder or posttraumatic stress disorder (PTSD).
Psychopharmacological drug Paroxetine (Paxil) is an antidepressant, which belongs to the group of SSRIs (selective serotonin reuptake inhibitors). The drug is available in the form of biconvex oval tablets coated with a film shell of 20 mg Paroxetine in the form of hemihydrate hydrochloride.
Paxil is included in the list of vital and essential drugs. Today there are a lot of generics of Paroxetine.
Pharmacological Effect
Antidepressant Paroxetine from the group of the SIOZ with a pronounced anti-anxiety and anxiolytic effect has a bicyclic structure, that distinguishes it from other common thymoanaleptic.
Thymoanaleptic effect is due to the fact that the active substance paroxetine is able to selectively block the reverse capture of serotonin, so that its effect on the Central nervous system is much higher than the effect of other antidepressants.
The drug has a minimal effect on dopaminergic and histamine (H1) receptors slightly, so the severity of side effects from its use is minimal.
According to the instructions for use after oral administration, the drug quickly dissolves in the gastrointestinal tract, eating its absorption does not affect.
Paroxetine is excreted unchanged mainly by the liver (Metabolite - 64%), small amounts of urine and bile. The half-life is 16-24 hours.
Against the background of continuous long-term therapy pharmacokinetic parameters remain unchanged.
Application of Paroxetine
In the official summary it is reported that the tablets for oral administration of Paroxetine is used for relief of such mental disorders:
- Depressions;
- Generalized and post-traumatic stress disorder;
- Obsessive-compulsive disorder;
- Social phobias of different Genesis;
- Panic attack.
The drug is not used in pediatric practice due to the high risk of undesirable clinical outcomes (increased depression, aggressive behavior). With caution used during pregnancy and in the planning of conception due to possible malformations of the fetus.
The drug Paroxetine can be prescribed for the elderly, but the dosage is selected individually for each patient.
Patients with impaired work of the kidneys and liver therapeutic treatment is carried out under the strict supervision of a specialist, the dosage for such patients should be minimal.
Method of application and dosage
The drug Paroxetine is intended for oral administration, the recommended initial dose-20 mg once in the morning with food. Tablet drink whole, without chewing.
During Paroxetine treatment, the dosage is selected individually for each individual patient based on clinical symptoms. The correct dose is established during the first 2-3 weeks of therapy by a qualified specialist.
Therapeutic treatment is usually long, it is necessary for relief of mental disorders.In the treatment of depression, the course of therapy can last several months continuously, obsessive-compulsive and panic disorders are treated even longer.
It is not recommended to suddenly cancel antidepressants, because it is fraught with withdrawal syndrome.
For relief of depressive disorders, the optimal initial dosage is 20 mg/day, which must be increased (adding 10 mg) until a stable therapeutic effect. The maximum daily dose is 50 mg.
Panic disorders: the recommended initial dosage is 10 mg, with a gradual increase on a weekly basis (10 mg) until the desired effect is obtained. The optimal dosage is -40 mg per day. A maximum of 50 mg/day. Improvement of the condition of such patients is possible only with the use of a maximum dose (50 mg). To relieve symptoms in the early stages, a minimum dosage is used.
Obsessive-compulsive disorder-the initial dose-20 mg, then gradually increase (10 mg more weekly) 40 mg/day in two doses. The maximum dosage is 60 mg. in selected patients with persistent therapeutic effectivene to achieve using maximum dosage per day.
In the presence of post - traumatic, generalized disorders and social phobias, the dosage is selected individually, initially-10 mg/day. with a weekly increase of up to 50 mg/day, the dose may be lower if the positive effect occurs when using lower doses.
The scheme of therapy and duration of treatment can be prescribed by the treating specialist for each patient individually. Paroxetine (Paxil) can be used for a long time, as well as for preventive purposes. Please read the attached annotation before use.
Withdrawal of Paroxetine
Paroxetine tablets as well as other psychotropic drugs require compliance with all the prescriptions of the attending physician. You should avoid a sharp withdrawal of the drug, the dose is reduced gradually, with each week the amount of medication taken is reduced by 10 mg, this reduces the risk of undesirable symptoms.
In those cases, when in the process of cancellation of treatment appeared undesirable clinical symptoms, it is necessary to contact the treating specialist, who will prescribe a second course of treatment in the previous dose. Later, you can continue to reduce the dose, but more gradually.
The rules of drug withdrawal are determined by the attending specialist depending on the severity of mental disorders and the General condition of the patient.
Contraindications and additional information
The official instructions for use stated, the drug is contraindicated in such cases:
- Children's age (up to 18 years);
- For patients who take MAO, pemoside, tryptophan, thioridazine;
- Lactation (the drug penetrates into breast milk);
- Increased individual sensitivity to paroxetine and other auxiliary components;
- Caution should be exercised in the presence of renal and hepatic symptoms.
Clinical experience with paroxetine suggests that it does not worsen cognitive and psychomotor functions. At the same time, there were reviews of drowsiness on the background of Paroxetine therapy.
Patients who are taking Paroxetine and other thymoanaleptic be careful when driving and when in contact with any mechanisms.
Despite the fact that the drug does not increase the negative impact of ethanol on psychomotor function, it is not recommended to use Paroxetine and alcohol at the same time.
Rules of use during pregnancy
With regard to the treatment Maxilom and other SIOZ during pregnancy, they can be taken only in those cases where the presumed benefit to the mother is greater than the risk to the fetus. In any case, it is necessary to consider the alternative treatment of pregnant women or women planning to conceive. There are reviews of the negative impact of the drug on the course of pregnancy (the risk of premature labor), but the causal relationship between the reception of SIOZ and preterm birth to date has not been recorded.
Application in childhood and adolescence
Tablet Paroxetine not used for the treatment of children even in the most minimal dose.
Therapy of mental disorders with paxil tablets in persons from 18 years of age in the initial stages is associated with an increased risk of suicidal tendencies (suicide or suicidal behavior) against the background of such treatment.
At the beginning of therapy at persons of young age there have also been instances of suicidal behavior (irritability, impulsivity, aggression) on the background of treatment with paxil medication and its analogues.
Spillover effects
As a rule, it is well tolerated, but if abused, systemic side effects may occur due to the action of the paroxetine. Side effects include:
- VNS: dry mouth, increased sweating;
- Central nervous system: insomnia or drowsiness, nervousness, aggression, dizziness, headache, depression, memory problems, hallucinations, akathisia, tremor, paresthesia, approbate, myoclonus, asthenia.
- GI: diarrhea or constipation, nausea, loss of appetite, vomiting, weight gain, hepatotonic effect (increased liver transaminases);
- Lymphatic and CCC: tachycardia, hypotension or hypertension, leukopenia, anemia, bradycardia, risk of bleeding (against the background of taking anticoagulants), hematomas;
- Respiratory system: sinusitis, respiratory disorders;
- Endocrine system: risk of hyperprolactinemia;
- Sexual and urinary system: urinary disorders, decreased libido, impotence;
- Additional: allergic skin reactions, malaise, migraine, chills, swelling and hyperemia of the face, neck pain and fainting, visual impairment, galactorrhea (nursing mothers).
In patients with depressive and bipolar affective disorders pills Paroxetine can lead to the development of mania and hypomania.
If you have any similar symptoms, you should stop taking the medication and seek immediate, qualified help.
Drug interaction
On the background of the application along with the irreversible MAO inhibitors, tramadol, triptans there is a risk of serotonin sydrome - a deadly side effect.
In the instructions for use indicated that Paroxetine not working with tetra-antidepressants, anticonvulsive funds, methylene blue, barbiturates, reversible and irreversible MAO inhibitors, warfarin, imipramine, bupropion, nortriptyline tryptophan and trazodone.
The simultaneous use of paroxetine with phenothiazine derivatives (antidepressant) dosage should be agreed with your doctor.
In the course of clinical studies, it was found that the pharmacokinetic properties of paroxetine are not affected: antacids, digoxin and food, the combination of these drugs does not require dose adjustment.
In patients who use anticoagulants, the drug can cause bleeding, because you need to carefully monitor the condition of such patients.
Paroxetine medicine does not have negative reactions caused by the action of ethanol on mental abilities and motor skills, but it is not recommended to use ethanol containing drugs and alcohol during treatment with the drug.
Possibility of overdose
The most common signs of an overdose of paxil tablets include:
- Mental confusion;
- Drowsiness;
- Heart rate disorder;
- Nausea;
- A sharp drop or increase in blood pressure;
- Manic state;
- Mydriasis;
- Coma;
- Dizziness;
- Aggression;
- Liver failure (clinical signs of hepatitis and cirrhosis);
- Delay urination.
The simultaneous use of Paroxetine in a toxic dosage and its analogues with alcohol and psychotropics can lead to death.
In case of overdose, symptomatic therapy is prescribed, for example:
- Gastric lavage;
- The appointment of adsorbents (activated carbon);
- Artificial vomiting.
In severe cases, treatment in the hospital with the use of detoxification measures is indicated. There is no specific antidote. In severe cases, you need to control heart activity, breathing (artificial ventilation of the lungs).
Paroxetine (Paxil): Analogues
Structural analogues of the active substance:
Of paroxetine hydrochloride hemihydrate, Adepress, Plasil, Rexetin, Carestill.
These drugs have the same composition, for more detailed information, you can study the feedback of patients.
Currently, there are drugs similar to the drug Paroxetine in its action.
In the pharmacy network can be individually purchased the medicines with a similar composition, for example, analogs in the pharmacological group (thymoanaleptic): Amitriptyline, Oprah, Laminal, DULOXETINE, Marazita, Fevarin, Darton, Amisol, Pirazidol, Efevelone, Amixed, Clomipram,Negrustin, Velaxin, venlafaxine, Lanoxin, Fluoxetine, Tryptizol, Feralzen, Heptral, Deprax, Doxepin, Zoloft, Europlant, Clomipramine, Coaxil, Lerivon, Prodep, Mianzan, Cipralex, Mirzaten, Prozac, Citalopram Cipramil, Bertalan, Stimuloton, Framex, Seropram, Proflusak, Remeron, Noxibel, Level.
Independently replace Paroxetine with other, similar in effect medicines is not recommended, this requires the advice of a treating specialist-psychiatrist.
Reviews of the drug
Paroxetine tablets are available Laboratoire GlaxoSmithKline in France, this drug is widely used in medical practice, consider the reviews about it.
Dignities:
- Gives the effect when used correctly;
- Relieves the symptoms of depression, tearfulness;
- Helps with anxiety / panic disorder.
Disadvantages:
- There are various side effects, pronounced withdrawal syndrome;
- Appointed strictly by appointment of a qualified specialist (psychiatrist);
- Weight gain, severe withdrawal syndrome, high price;
- Risk of suicidal tendencies;
- Drowsiness or Vice versa excitation.
Summing up the results of the considered drug, it is possible to identify the main key features of this antidepressant, which can affect the patient's condition both in the positive and in the negative direction. First of all, it should be noted that the drug copes with the main functions assigned to it, namely, to promote the restoration of normal mental activity of a person. However, the drug has a number of negative properties that can affect both the physical and emotional state of patients(aggressiveness, addiction, suicidal behavior and thoughts).
All the above information is for informational purposes only. Before therapy, read the instructions for use in detail and be sure to consult a qualified psychiatrist, do not self-medicate, it can only aggravate the situation. Only a qualified specialist can decide on the need for therapy with a specific drug, as well as determine the dosage and duration of treatment.